Mexico the Commission on human rights, CNDH, said 5,397 people had been missing since President Felipe Calderon declared war on the drug cartels.
A study of the United Nations has proposed that the security forces may also have played a role in the disappearance of a number of those missing.
Mr Calderon has 50,000 troops deployed as part of its war on the cartels.
The CNDH by family members and Government-provided data is collected and all of these "missing or absent".
The Commission said 3,457 men of which had disappeared and 1,778 women, while there is no data on the remaining 55 cases.
The CNDH said that it was research into the reasons behind the disappearances, and stated that the figure included that kidnapped for ransom and economic migrants in Mexico and Central America whose whereabouts were unknown.
The figures were released just days after the United Nations Working Group on enforced or involuntary disappearances said that the reports of several cases of forced disappearances allegedly carried out by Mexican soldiers have received.
The Group of the UN urged the Mexican Government to stop using the military in drug operations.
President Calderon deployed the army in an attempt to curb the violence of the country's drug cartels which killed more than 34,000 since he took office.
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